Protein methionine oxidation augments reperfusion injury in acute ischemic stroke

Reperfusion injury can exacerbate tissue damage in ischemic stroke, but little is known about the mechanisms linking ROS to stroke severity. Here, we tested the hypothesis that protein methionine oxidation potentiates NF-κB activation and contributes to cerebral ischemia/reperfusion injury. We found...

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發表在:JCI Insight
Main Authors: Gu, Sean X., Blokhin, Ilya O., Wilson, Katina M., Dhanesha, Nirav, Doddapattar, Prakash, Grumbach, Isabella M., Chauhan, Anil K., Lentz, Steven R.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2016
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902298/
https://ncbi.nlm.nih.gov/pubmed/27294204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86460
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