Protein methionine oxidation augments reperfusion injury in acute ischemic stroke

Reperfusion injury can exacerbate tissue damage in ischemic stroke, but little is known about the mechanisms linking ROS to stroke severity. Here, we tested the hypothesis that protein methionine oxidation potentiates NF-κB activation and contributes to cerebral ischemia/reperfusion injury. We found...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Gu, Sean X., Blokhin, Ilya O., Wilson, Katina M., Dhanesha, Nirav, Doddapattar, Prakash, Grumbach, Isabella M., Chauhan, Anil K., Lentz, Steven R.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902298/
https://ncbi.nlm.nih.gov/pubmed/27294204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86460
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