Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy

Macroautophagy (hereafter autophagy) is the major pathway by which macromolecules and organelles are degraded. Autophagy is regulated by the mTOR signaling pathway – the focal point for integration of metabolic information, with mTORC1 playing a central role in balancing biosynthesis and catabolism....

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發表在:Cell Metab
Main Authors: Dubinsky, Amy N., Dastidar, Somasish Ghosh, Hsu, Cynthia L., Zahra, Rabaab, Djakovic, Stevan, Duarte, Sonia, Esau, Christine C., Spencer, Brian, Ashe, Travis D., Fischer, Kimberlee M., MacKenna, Deidre A., Sopher, Bryce L., Masliah, Eliezer, Gaasterland, Terry, Chau, B. Nelson, de Almeida, Luis Pereira, Morrison, Bradley E., La Spada, Albert R.
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245205/
https://ncbi.nlm.nih.gov/pubmed/25295787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.09.001
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