Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly

Yazar: Bennett, Craig L., Sopher, Bryce L., La Spada, Albert R.
Yayımlandı Heliyon (2020)

Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58(IPK)

Yazar: Yan, Wei, Frank, Christopher L., Korth, Marcus J., Sopher, Bryce L., Novoa, Isabel, Ron, David, Katze, Michael G.
Baskı/Yayın Bilgisi 2002

Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals

Yazar: Guo, Qing, Sopher, Bryce L., Furukawa, Katsutoshi, Pham, Dao G., Robinson, Nic, Martin, George M., Mattson, Mark P.
Yayımlandı J Neurosci (1997)

The zinc-binding domain of Nna1 is required to prevent retinal photoreceptor loss and cerebellar ataxia in Purkinje cell degeneration (pcd) mice

Yazar: Chakrabarti, Lisa, Eng, Jeremiah, Martinez, Refugio A., Jackson, Stephen, Huang, Jing, Possin, Daniel E., Sopher, Bryce L., La Spada, Albert R.
Baskı/Yayın Bilgisi 2008

Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mu...

Yazar: Guo, Qing, Sebastian, Lois, Sopher, Bryce L., Miller, Miles W., Glazner, Gordon W., Ware, Carol B., Martin, George M., Mattson, Mark P.
Baskı/Yayın Bilgisi 1999

4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response

Yazar: Dastidar, Somasish Ghosh, Pham, Michael T., Mitchell, Matthew B., Yeom, Steven G., Jordan, Sarah, Chang, Angela, Sopher, Bryce L., La Spada, Albert R.
Yayımlandı J Neurosci (2020)

Spinocerebellar Ataxia Type 7 Cerebellar Disease Requires the Coordinated Action of Mutant Ataxin-7 in Neurons and Glia, and Displays Non-Cell-Autonomous Bergmann Glia Degeneration

Yazar: Furrer, Stephanie A., Mohanachandran, Mathini S., Waldherr, Sarah M., Chang, Christopher, Damian, Vincent A., Sopher, Bryce L., Garden, Gwenn A., La Spada, Albert R.
Baskı/Yayın Bilgisi 2011

Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction

Yazar: Guyenet, Stephan J., Mookerjee, Shona S., Lin, Amy, Custer, Sara K., Chen, Sylvia F., Sopher, Bryce L., La Spada, Albert R., Ellerby, Lisa M.
Yayımlandı Hum Mol Genet (2015)

Bax Interacting Factor-1 Promotes Survival and Mitochondrial Elongation in Neurons

Yazar: Wang, David B., Uo, Takuma, Kinoshita, Chizuru, Sopher, Bryce L., Lee, Rona J., Murphy, Sean P., Kinoshita, Yoshito, Garden, Gwenn A., Wang, Hong-Gang, Morrison, Richard S.
Baskı/Yayın Bilgisi 2014

Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7

Yazar: Furrer, Stephanie A., Waldherr, Sarah M., Mohanachandran, Mathini S., Baughn, Travis D., Nguyen, Kien-Thiet, Sopher, Bryce L., Damian, Vincent A., Garden, Gwenn A., La Spada, Albert R.
Baskı/Yayın Bilgisi 2013

Posttranslational Modification of Ataxin-7 at Lysine 257 Prevents Autophagy-Mediated Turnover of an N-Terminal Caspase-7 Cleavage Fragment

Yazar: Mookerjee, Shona, Papanikolaou, Theodora, Guyenet, Stephan J., Sampath, Vanitha, Lin, Amy, Vitelli, Cathy, DeGiacomo, Francesco, Sopher, Bryce L., Chen, Sylvia F., La Spada, Albert R., Ellerby, Lisa M.
Baskı/Yayın Bilgisi 2009

CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense non-coding RNA

Yazar: Sopher, Bryce L., Ladd, Paula D., Pineda, Victor V., Libby, Randell T., Sunkin, Susan M., Hurley, James B., Thienes, Cortlandt P., Gaasterland, Terry, Filippova, Galina N., La Spada, Albert R.
Baskı/Yayın Bilgisi 2011

Neuronal susceptibility to beta‐amyloid toxicity and ischemic injury involves histone deacetylase‐2 regulation of endophilin‐B1

Yazar: Wang, David B., Kinoshita, Chizuru, Kinoshita, Yoshito, Sopher, Bryce L., Uo, Takuma, Lee, Rona J., Kim, Joon Kyu, Murphy, Sean P., Dirk Keene, C., Garden, Gwenn A., Morrison, Richard S.
Yayımlandı Brain Pathol (2018)

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit pathological autophagy defects in SBMA

Yazar: Cortes, Constanza J., Miranda, Helen C., Frankowski, Harald, Batlevi, Yakup, Young, Jessica E., Le, Amy, Ivanov, Nishi, Sopher, Bryce L., Carromeu, Cassiano, Muotri, Alysson R., Garden, Gwenn A., La Spada, Albert R.
Baskı/Yayın Bilgisi 2014

Loss of endophilin-B1 exacerbates Alzheimer’s disease pathology

Yazar: Wang, David B., Kinoshita, Yoshito, Kinoshita, Chizuru, Uo, Takuma, Sopher, Bryce L., Cudaback, Eiron, Keene, C. Dirk, Bilousova, Tina, Gylys, Karen, Case, Amanda, Jayadev, Suman, Wang, Hong-Gang, Garden, Gwenn A., Morrison, Richard S.
Yayımlandı Brain (2015)

Muscle expression of mutant androgen receptor protein accounts for systemic and motor neuron disease phenotypes in Spinal & Bulbar Muscular Atrophy

Yazar: Cortes, Constanza J., Ling, Shuo-Chien, Guo, Ling T., Hung, Gene, Tsunemi, Taiji, Ly, Linda, Tokunaga, Seiya, Lopez, Edith, Sopher, Bryce L., Bennett, C. Frank, Shelton, G. Diane, Cleveland, Don W., La Spada, Albert R.
Baskı/Yayın Bilgisi 2014

Polyglutamine-Expanded Androgen Receptor Truncation Fragments Activate a Bax-Dependent Apoptotic Cascade Mediated by DP5/Hrk

Yazar: Young, Jessica E., Garden, Gwenn A., Martinez, Refugio A., Tanaka, Fumiaki, Miguel Sandoval, C., Smith, Annette C., Sopher, Bryce L., Lin, Amy, Fischbeck, Kenneth H., Ellerby, Lisa M., Morrison, Richard S., Taylor, J. Paul, La Spada, Albert R.
Baskı/Yayın Bilgisi 2009

Antisense oligonucleotides targeting mutant Ataxin-7 restore visual function in a mouse model of spinocerebellar ataxia type 7

Yazar: Niu, Chenchen, Prakash, Thazah P., Kim, Aneeza, Quach, John L., Huryn, Laryssa A., Yang, Yuechen, Lopez, Edith, Jazayeri, Ali, Hung, Gene, Sopher, Bryce L., Brooks, Brian P., Swayze, Eric E., Bennett, C. Frank, La Spada, Albert R.
Yayımlandı Sci Transl Med (2018)

A Novel Antisense CAG Repeat Transcript at JPH3 Locus Mediating Expanded Polyglutamine Protein Toxicity in Huntington’s Disease-Like 2 (HDL2) Mice

Yazar: Wilburn, Brian, Rudnicki, Dobrila D., Zhao, Jing, Weitz, Tara Murphy, Cheng, Yin, Gu, Xiaofeng, Greiner, Erin, Park, Chang Sin, Wang, Nan, Sopher, Bryce L., La Spada, Albert R., Osmand, Alex, Margolis, Russell L., Sun, Yi E., Yang, X. William
Baskı/Yayın Bilgisi 2011

CTCF cis-Regulates Trinucleotide Repeat Instability in an Epigenetic Manner: A Novel Basis for Mutational Hot Spot Determination

Yazar: Libby, Randell T., Hagerman, Katharine A., Pineda, Victor V., Lau, Rachel, Cho, Diane H., Baccam, Sandy L., Axford, Michelle M., Cleary, John D., Moore, James M., Sopher, Bryce L., Tapscott, Stephen J., Filippova, Galina N., Pearson, Christopher E., La Spada, Albert R.
Baskı/Yayın Bilgisi 2008