Cardiac Myocyte Z-line Calmodulin is Mainly RyR2-Bound and Reduction is Arrhythmogenic and Occurs in Heart Failure

RATIONALE: Calmodulin (CaM) associates with cardiac ryanodine receptors (RyR2) as an important regulator. Defective CaM-RyR2 interaction may occur in heart failure (HF), cardiac hypertrophy, and catecholaminergic polymorphic ventricular tachycardia (CPVT). However, the in situ binding properties for...

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Main Authors: Yang, Yi, Guo, Tao, Oda, Tetsuro, Chakraborty, Asima, Chen, Le, Uchinoumi, Hitoshi, Knowlton, Anne A., Fruen, Bradley R., Cornea, Razvan L., Meissner, Gerhard, Bers, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004530/
https://ncbi.nlm.nih.gov/pubmed/24186966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.302857
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