An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes methylation of histone H3 lysine 27 (H3K27). The trimethylation of H3K27 (H3K27me3) is a transcriptionally repressive post-translational modification. Overexpression of EZH2 and hypertrimethylation of H3K27 hav...

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Detalhes bibliográficos
Main Authors: Konze, Kyle D., Ma, Anqi, Li, Fengling, Barsyte-Lovejoy, Dalia, Parton, Trevor, MacNevin°, Christopher J., Liu, Feng, Gao, Cen, Huang, Xi-Ping, Kuznetsova, Ekaterina, Rougie°, Marie, Jiang, Alice, Pattenden, Samantha G., Norris, Jacqueline L., James, Lindsey I., Roth, Bryan L., Brown, Peter J., Frye, Stephen V., Arrowsmith, Cheryl H., Hahn°, Klaus M., Wang, Gang Greg, Vedadi, Masoud, Jin, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773059/
https://ncbi.nlm.nih.gov/pubmed/23614352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400133j
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