Structure–Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors

EZH2 or EZH1 (enhancer of zeste homologue 2 or 1) is the catalytic subunit of polycomb repressive complex 2 (PRC2) that catalyzes methylation of histone H3 lysine 27 (H3K27). PRC2 hyperactivity and/or hypertrimethylation of H3K27 are associated with numerous human cancers, therefore inhibition of PR...

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Pubblicato in:J Med Chem
Autori principali: Yang, Xiaobao, Li, Fengling, Konze, Kyle D., Meslamani, Jamel, Ma, Anqi, Brown, Peter J., Zhou, Ming-Ming, Arrowsmith, Cheryl H., Kaniskan, H. Ümit, Vedadi, Masoud, Jin, Jian
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003625/
https://ncbi.nlm.nih.gov/pubmed/27468126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00855
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