Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

Enhancer of zeste homolog 2 (EZH2) and related EZH1 control gene expression and promote tumorigenesis via methylating histone H3 at lysine 27 (H3K27). These methyltransferases are ideal therapeutic targets due to their frequent hyperactive mutations and overexpression found in cancer, including hema...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood
Main Authors: Xu, Bowen, On, Doan M., Ma, Anqi, Parton, Trevor, Konze, Kyle D., Pattenden, Samantha G., Allison, David F., Cai, Ling, Rockowitz, Shira, Liu, Shichong, Liu, Ying, Li, Fengling, Vedadi, Masoud, Frye, Stephen V., Garcia, Benjamin A., Zheng, Deyou, Jin, Jian, Wang, Gang Greg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287641/
https://ncbi.nlm.nih.gov/pubmed/25395428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-581082
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados