Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

Enhancer of zeste homolog 2 (EZH2) and related EZH1 control gene expression and promote tumorigenesis via methylating histone H3 at lysine 27 (H3K27). These methyltransferases are ideal therapeutic targets due to their frequent hyperactive mutations and overexpression found in cancer, including hema...

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Udgivet i:Blood
Main Authors: Xu, Bowen, On, Doan M., Ma, Anqi, Parton, Trevor, Konze, Kyle D., Pattenden, Samantha G., Allison, David F., Cai, Ling, Rockowitz, Shira, Liu, Shichong, Liu, Ying, Li, Fengling, Vedadi, Masoud, Frye, Stephen V., Garcia, Benjamin A., Zheng, Deyou, Jin, Jian, Wang, Gang Greg
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2015
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287641/
https://ncbi.nlm.nih.gov/pubmed/25395428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-581082
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