Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

Enhancer of zeste homolog 2 (EZH2) and related EZH1 control gene expression and promote tumorigenesis via methylating histone H3 at lysine 27 (H3K27). These methyltransferases are ideal therapeutic targets due to their frequent hyperactive mutations and overexpression found in cancer, including hema...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Blood
Main Authors: Xu, Bowen, On, Doan M., Ma, Anqi, Parton, Trevor, Konze, Kyle D., Pattenden, Samantha G., Allison, David F., Cai, Ling, Rockowitz, Shira, Liu, Shichong, Liu, Ying, Li, Fengling, Vedadi, Masoud, Frye, Stephen V., Garcia, Benjamin A., Zheng, Deyou, Jin, Jian, Wang, Gang Greg
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2015
Teme:
Myeloid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287641/
https://ncbi.nlm.nih.gov/pubmed/25395428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-581082
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki