Critical role of Jumonji domain of JMJD1C in MLL-rearranged leukemia

JMJD1C, a member of the lysine demethylase 3 family, is aberrantly expressed in mixed lineage leukemia (MLL) gene-rearranged (MLLr) leukemias. We have shown previously that JMJD1C is required for self-renewal of acute myeloid leukemia (AML) leukemia stem cells (LSCs) but not normal hematopoietic ste...

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Detalles Bibliográficos
Publicado en:Blood Adv
Autores principales: Izaguirre-Carbonell, Jesus, Christiansen, Luke, Burns, Robert, Schmitz, Jesse, Li, Chenxuan, Mokry, Rebekah L., Bluemn, Theresa, Zheng, Yongwei, Shen, Jian, Carlson, Karen-Sue, Rao, Sridhar, Wang, Demin, Zhu, Nan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2019
Materias:
Myeloid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517669/
https://ncbi.nlm.nih.gov/pubmed/31076406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018026054
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