Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

Enhancer of zeste homolog 2 (EZH2) and related EZH1 control gene expression and promote tumorigenesis via methylating histone H3 at lysine 27 (H3K27). These methyltransferases are ideal therapeutic targets due to their frequent hyperactive mutations and overexpression found in cancer, including hema...

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Pubblicato in:Blood
Autori principali: Xu, Bowen, On, Doan M., Ma, Anqi, Parton, Trevor, Konze, Kyle D., Pattenden, Samantha G., Allison, David F., Cai, Ling, Rockowitz, Shira, Liu, Shichong, Liu, Ying, Li, Fengling, Vedadi, Masoud, Frye, Stephen V., Garcia, Benjamin A., Zheng, Deyou, Jin, Jian, Wang, Gang Greg
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2015
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287641/
https://ncbi.nlm.nih.gov/pubmed/25395428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-581082
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