A chemical tool for chemiprecipitation of the lysine methyltransferase, G9a, in vitro and in vivo

Here we report the design, synthesis, and biochemical characterization of a new chemical tool, UNC0965. UNC0965 is a biotinylated version of our previously reported G9a chemical probe, UNC0638. Importantly, UNC0965 maintains high in vitro potency and is cell penetrant. The biotinylated tag of UNC096...

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Библиографические подробности
Главные авторы: Konze, Kyle D., Pattenden, Samantha G., Liu, Feng, Barsyte-Lovejoy, Dalia, Li, Fengling, Simon, Jeremy M., Davis, Ian J., Vedadi, Masoud, Jin, Jian
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005005/
https://ncbi.nlm.nih.gov/pubmed/24443078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300450
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