Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase

G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately 80% sequence identity in their catalytic domains. GLP and G9a form a heterodimer complex and catalyze mono- and dimethylation of histone H3 lysine 9 and nonhistone substrates. Althoug...

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Published in:J Med Chem
Main Authors: Xiong, Yan, Li, Fengling, Babault, Nicolas, Dong, Aiping, Zeng, Hong, Wu, Hong, Chen, Xin, Arrowsmith, Cheryl H., Brown, Peter J., Liu, Jing, Vedadi, Masoud, Jin, Jian
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352984/
https://ncbi.nlm.nih.gov/pubmed/28135087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01645
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