Structure-activity relationship studies of G9a-like protein (GLP) inhibitors

Given the high homology between the protein lysine methyltransferases G9a-like protein (GLP) and G9a, it has been challenging to develop potent and selective inhibitors for either enzyme. Recently, we reported two quinazoline compounds, MS0124 and MS012, as GLP selective inhibitors. To further inves...

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Bibliografske podrobnosti
izdano v:Bioorg Med Chem
Main Authors: Xiong, Yan, Li, Fengling, Babault, Nicolas, Wu, Hong, Dong, Aiping, Zeng, Hong, Chen, Xin, Arrowsmith, Cheryl H., Brown, Peter J., Liu, Jing, Vedadi, Masoud, Jin, Jian
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562403/
https://ncbi.nlm.nih.gov/pubmed/28662962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.06.021
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