Structure-activity relationship studies of G9a-like protein (GLP) inhibitors

Given the high homology between the protein lysine methyltransferases G9a-like protein (GLP) and G9a, it has been challenging to develop potent and selective inhibitors for either enzyme. Recently, we reported two quinazoline compounds, MS0124 and MS012, as GLP selective inhibitors. To further inves...

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Vydáno v:Bioorg Med Chem
Hlavní autoři: Xiong, Yan, Li, Fengling, Babault, Nicolas, Wu, Hong, Dong, Aiping, Zeng, Hong, Chen, Xin, Arrowsmith, Cheryl H., Brown, Peter J., Liu, Jing, Vedadi, Masoud, Jin, Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562403/
https://ncbi.nlm.nih.gov/pubmed/28662962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.06.021
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