Purified and synthetic Alzheimer’s amyloid beta (Aβ) prions

The aggregation and deposition of amyloid-β (Aβ) peptides are believed to be central events in the pathogenesis of Alzheimer’s disease (AD). Inoculation of brain homogenates containing Aβ aggregates into susceptible transgenic mice accelerated Aβ deposition, suggesting that Aβ aggregates are capable...

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Detalles Bibliográficos
Autores principales: Stöhr, Jan, Watts, Joel C., Mensinger, Zachary L., Oehler, Abby, Grillo, Sunny K., DeArmond, Stephen J., Prusiner, Stanley B., Giles, Kurt
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390876/
https://ncbi.nlm.nih.gov/pubmed/22711819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206555109
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