Purified and synthetic Alzheimer’s amyloid beta (Aβ) prions

The aggregation and deposition of amyloid-β (Aβ) peptides are believed to be central events in the pathogenesis of Alzheimer’s disease (AD). Inoculation of brain homogenates containing Aβ aggregates into susceptible transgenic mice accelerated Aβ deposition, suggesting that Aβ aggregates are capable...

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Autors principals: Stöhr, Jan, Watts, Joel C., Mensinger, Zachary L., Oehler, Abby, Grillo, Sunny K., DeArmond, Stephen J., Prusiner, Stanley B., Giles, Kurt
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390876/
https://ncbi.nlm.nih.gov/pubmed/22711819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206555109
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