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Evidence That Bank Vole PrP Is a Universal Acceptor for Prions

Bank voles are uniquely susceptible to a wide range of prion strains isolated from many different species. To determine if this enhanced susceptibility to interspecies prion transmission is encoded within the sequence of the bank vole prion protein (BVPrP), we inoculated Tg(M109) and Tg(I109) mice,...

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Detalhes bibliográficos
Main Authors: Watts, Joel C., Giles, Kurt, Patel, Smita, Oehler, Abby, DeArmond, Stephen J., Prusiner, Stanley B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974871/
https://ncbi.nlm.nih.gov/pubmed/24699458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003990
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