Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein

Currently, there are no animal models of the most common human prion disorder, sporadic Creutzfeldt-Jakob disease (CJD), in which prions are formed spontaneously from wild-type (WT) prion protein (PrP). Interestingly, bank voles (BV) exhibit an unprecedented promiscuity for diverse prion isolates, a...

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Bibliographic Details
Main Authors: Watts, Joel C., Giles, Kurt, Stöhr, Jan, Oehler, Abby, Bhardwaj, Sumita, Grillo, Sunny K., Patel, Smita, DeArmond, Stephen J., Prusiner, Stanley B.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295307/
https://ncbi.nlm.nih.gov/pubmed/22331873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121556109
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