Protease-Resistant Prions Selectively Decrease Shadoo Protein

The central event in prion diseases is the conformational conversion of the cellular prion protein (PrP(C)) into PrP(Sc), a partially protease-resistant and infectious conformer. However, the mechanism by which PrP(Sc) causes neuronal dysfunction remains poorly understood. Levels of Shadoo (Sho), a...

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Главные авторы: Watts, Joel C., Stöhr, Jan, Bhardwaj, Sumita, Wille, Holger, Oehler, Abby, DeArmond, Stephen J., Giles, Kurt, Prusiner, Stanley B.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219722/
https://ncbi.nlm.nih.gov/pubmed/22163178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002382
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