Spontaneous generation of anchorless prions in transgenic mice

Some prion protein mutations create anchorless molecules that cause Gerstmann–Sträussler–Scheinker (GSS) disease. To model GSS, we generated transgenic mice expressing cellular prion protein (PrP(C)) lacking the glycosylphosphatidyl inositol (GPI) anchor, denoted PrP(ΔGPI). Mice overexpressing PrP(Δ...

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Detalhes bibliográficos
Main Authors: Stöhr, Jan, Watts, Joel C., Legname, Giuseppe, Oehler, Abby, Lemus, Azucena, Nguyen, Hoang-Oanh B., Sussman, Joshua, Wille, Holger, DeArmond, Stephen J., Prusiner, Stanley B., Giles, Kurt
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248514/
https://ncbi.nlm.nih.gov/pubmed/22160704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117827108
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