Spontaneous generation of anchorless prions in transgenic mice

Some prion protein mutations create anchorless molecules that cause Gerstmann–Sträussler–Scheinker (GSS) disease. To model GSS, we generated transgenic mice expressing cellular prion protein (PrP(C)) lacking the glycosylphosphatidyl inositol (GPI) anchor, denoted PrP(ΔGPI). Mice overexpressing PrP(Δ...

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Détails bibliographiques
Auteurs principaux: Stöhr, Jan, Watts, Joel C., Legname, Giuseppe, Oehler, Abby, Lemus, Azucena, Nguyen, Hoang-Oanh B., Sussman, Joshua, Wille, Holger, DeArmond, Stephen J., Prusiner, Stanley B., Giles, Kurt
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2011
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248514/
https://ncbi.nlm.nih.gov/pubmed/22160704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117827108
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