Spontaneous generation of anchorless prions in transgenic mice

Some prion protein mutations create anchorless molecules that cause Gerstmann–Sträussler–Scheinker (GSS) disease. To model GSS, we generated transgenic mice expressing cellular prion protein (PrP(C)) lacking the glycosylphosphatidyl inositol (GPI) anchor, denoted PrP(ΔGPI). Mice overexpressing PrP(Δ...

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Main Authors: Stöhr, Jan, Watts, Joel C., Legname, Giuseppe, Oehler, Abby, Lemus, Azucena, Nguyen, Hoang-Oanh B., Sussman, Joshua, Wille, Holger, DeArmond, Stephen J., Prusiner, Stanley B., Giles, Kurt
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2011
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248514/
https://ncbi.nlm.nih.gov/pubmed/22160704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117827108
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