Spontaneous generation of anchorless prions in transgenic mice

Some prion protein mutations create anchorless molecules that cause Gerstmann–Sträussler–Scheinker (GSS) disease. To model GSS, we generated transgenic mice expressing cellular prion protein (PrP(C)) lacking the glycosylphosphatidyl inositol (GPI) anchor, denoted PrP(ΔGPI). Mice overexpressing PrP(Δ...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Stöhr, Jan, Watts, Joel C., Legname, Giuseppe, Oehler, Abby, Lemus, Azucena, Nguyen, Hoang-Oanh B., Sussman, Joshua, Wille, Holger, DeArmond, Stephen J., Prusiner, Stanley B., Giles, Kurt
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2011
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248514/
https://ncbi.nlm.nih.gov/pubmed/22160704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117827108
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