Spontaneous generation of anchorless prions in transgenic mice

Some prion protein mutations create anchorless molecules that cause Gerstmann–Sträussler–Scheinker (GSS) disease. To model GSS, we generated transgenic mice expressing cellular prion protein (PrP(C)) lacking the glycosylphosphatidyl inositol (GPI) anchor, denoted PrP(ΔGPI). Mice overexpressing PrP(Δ...

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Detaylı Bibliyografya
Asıl Yazarlar: Stöhr, Jan, Watts, Joel C., Legname, Giuseppe, Oehler, Abby, Lemus, Azucena, Nguyen, Hoang-Oanh B., Sussman, Joshua, Wille, Holger, DeArmond, Stephen J., Prusiner, Stanley B., Giles, Kurt
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248514/
https://ncbi.nlm.nih.gov/pubmed/22160704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117827108
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