Transmission of multiple system atrophy prions to transgenic mice

Prions are proteins that adopt alternative conformations, which become self-propagating. Increasing evidence argues that prions feature in the synucleinopathies that include Parkinson’s disease, Lewy body dementia, and multiple system atrophy (MSA). Although TgM83(+/+) mice homozygous for a mutant A...

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Autori principali: Watts, Joel C., Giles, Kurt, Oehler, Abby, Middleton, Lefkos, Dexter, David T., Gentleman, Steve M., DeArmond, Stephen J., Prusiner, Stanley B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845125/
https://ncbi.nlm.nih.gov/pubmed/24218576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318268110
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