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Protease-Resistant Prions Selectively Decrease Shadoo Protein
The central event in prion diseases is the conformational conversion of the cellular prion protein (PrP(C)) into PrP(Sc), a partially protease-resistant and infectious conformer. However, the mechanism by which PrP(Sc) causes neuronal dysfunction remains poorly understood. Levels of Shadoo (Sho), a...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3219722/ https://ncbi.nlm.nih.gov/pubmed/22163178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002382 |
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