Towards authentic transgenic mouse models of heritable PrP prion diseases

Attempts to model inherited human prion disorders such as familial Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker (GSS) disease, and fatal familial insomnia (FFI) using genetically modified mice have produced disappointing results. We recently demonstrated that transgenic (Tg) mice...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Watts, Joel C., Giles, Kurt, Bourkas, Matthew E.C., Patel, Smita, Oehler, Abby, Gavidia, Marta, Bhardwaj, Sumita, Lee, Joanne, Prusiner, Stanley B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5152593/
https://ncbi.nlm.nih.gov/pubmed/27350609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1585-6
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