Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions

The biochemical and neuropathological properties of bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) prions are faithfully maintained upon transmission to guinea pigs. However, primary and secondary transmissions of BSE and vCJD in guinea pigs result in long incuba...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Watts, Joel C., Giles, Kurt, Saltzberg, Daniel J., Dugger, Brittany N., Patel, Smita, Oehler, Abby, Bhardwaj, Sumita, Sali, Andrej, Prusiner, Stanley B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Prions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068510/
https://ncbi.nlm.nih.gov/pubmed/27440899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01106-16
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