Purified and synthetic Alzheimer’s amyloid beta (Aβ) prions

The aggregation and deposition of amyloid-β (Aβ) peptides are believed to be central events in the pathogenesis of Alzheimer’s disease (AD). Inoculation of brain homogenates containing Aβ aggregates into susceptible transgenic mice accelerated Aβ deposition, suggesting that Aβ aggregates are capable...

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Bibliografiske detaljer
Main Authors: Stöhr, Jan, Watts, Joel C., Mensinger, Zachary L., Oehler, Abby, Grillo, Sunny K., DeArmond, Stephen J., Prusiner, Stanley B., Giles, Kurt
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390876/
https://ncbi.nlm.nih.gov/pubmed/22711819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206555109
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