Impaired Learning and Motor Behavior in Heterozygous Pafah1b1 (Lis1) Mutant Mice

Heterozygous mutation or deletion of Pafah1b1 (LIS1) in humans is associated with syndromes with type 1 lissencephaly, a severe brain developmental disorder resulting from abnormal neuronal migration. We have created Lis1 heterozygous mutant mice by gene targeting. Heterozygous mutant mice are viabl...

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Autori principali: Paylor, Richard, Hirotsune, Shinji, Gambello, Michael J., Yuva-Paylor, Lisa, Crawley, Jacqueline N., Wynshaw-Boris, Anthony
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 1999
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC311310/
https://ncbi.nlm.nih.gov/pubmed/10541472
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