The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensis

Lissencephaly is a devastating neurological disorder caused by to defective neuronal migration. LIS1 (or PAFAH1B1), the gene mutated in lissencephaly patients and its binding protein NDEL1 were found to regulate cytoplasmic dynein function and localization. LIS1 and NDEL1 also play a pivotal role on...

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Main Authors: Yamada, Masami, Hirotsune, Shinji, Wynshaw-Boris, Anthony
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2010
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900609/
https://ncbi.nlm.nih.gov/pubmed/20168084
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