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The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensis

Lissencephaly is a devastating neurological disorder caused by to defective neuronal migration. LIS1 (or PAFAH1B1), the gene mutated in lissencephaly patients and its binding protein NDEL1 were found to regulate cytoplasmic dynein function and localization. LIS1 and NDEL1 also play a pivotal role on...

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Detalhes bibliográficos
Main Authors: Yamada, Masami, Hirotsune, Shinji, Wynshaw-Boris, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900609/
https://ncbi.nlm.nih.gov/pubmed/20168084
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