LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein

LIS1 was first identified as a gene mutated in human classical lissencephaly sequence. LIS1 is required for dynein activity, but the underlying mechanism is poorly understood. Here, we demonstrate that LIS1 suppresses the motility of cytoplasmic dynein on microtubules (MTs), whereas NDEL1 releases t...

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Autors principals: Yamada, Masami, Toba, Shiori, Yoshida, Yuko, Haratani, Koji, Mori, Daisuke, Yano, Yoshihisa, Mimori-Kiyosue, Yuko, Nakamura, Takeshi, Itoh, Kyoko, Fushiki, Shinji, Setou, Mitsutoshi, Wynshaw-Boris, Anthony, Torisawa, Takayuki, Toyoshima, Yoko Y, Hirotsune, Shinji
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567412/
https://ncbi.nlm.nih.gov/pubmed/18784752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.182
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