LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein

LIS1 was first identified as a gene mutated in human classical lissencephaly sequence. LIS1 is required for dynein activity, but the underlying mechanism is poorly understood. Here, we demonstrate that LIS1 suppresses the motility of cytoplasmic dynein on microtubules (MTs), whereas NDEL1 releases t...

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Main Authors: Yamada, Masami, Toba, Shiori, Yoshida, Yuko, Haratani, Koji, Mori, Daisuke, Yano, Yoshihisa, Mimori-Kiyosue, Yuko, Nakamura, Takeshi, Itoh, Kyoko, Fushiki, Shinji, Setou, Mitsutoshi, Wynshaw-Boris, Anthony, Torisawa, Takayuki, Toyoshima, Yoko Y, Hirotsune, Shinji
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567412/
https://ncbi.nlm.nih.gov/pubmed/18784752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.182
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