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Novel Embryonic Neuronal Migration and Proliferation Defects in Dcx Mutant Mice Are Exacerbated by Lis1 Reduction

Heterozygous LIS1 mutations and males with loss of the X-linked DCX result in lissencephaly, a neuronal migration defect. LIS1 regulates nuclear translocation and mitotic division of neural progenitor cells, while the role of DCX in cortical development remains poorly understood. Here, we uncovered...

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Bibliographische Detailangaben
Hauptverfasser: Pramparo, Tiziano, Youn, Yong Ha, Yingling, Jessica, Hirotsune, Shinji, Wynshaw-Boris, Anthony
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861429/
https://ncbi.nlm.nih.gov/pubmed/20181597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4851-09.2010
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