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Inhibition of calpain increases LIS1(PAFAH1B1) and partially rescues in vivo phenotypes in a mouse model of lissencephaly
Lissencephaly is a devastating neurological disorder due to defective neuronal migration. LIS1 (or PAFAH1B1) was identified as the gene mutated in lissencephaly patients, and was found to regulate cytoplasmic dynein function and localization. Here, we show that more than half of LIS1 is degraded via...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2759411/ https://ncbi.nlm.nih.gov/pubmed/19734909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2023 |
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