A Low-Molecular-Weight Antagonist for the Human Thyrotropin Receptor with Therapeutic Potential for Hyperthyroidism

Low-molecular-weight (LMW) antagonists for TSH receptor (TSHR) may have therapeutic potential as orally active drugs to block stimulating antibodies (TsAbs) in Graves’ hyperthyroidism. We describe an approach to identify LMW ligands for TSHR based on Org41841, a LMW partial agonist for the LH/chorio...

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Detaylı Bibliyografya
Asıl Yazarlar: Neumann, Susanne, Kleinau, Gunnar, Costanzi, Stefano, Moore, Susanna, Jiang, Jian-kang, Raaka, Bruce M., Thomas, Craig J., Krause, Gerd, Gershengorn, Marvin C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Endocrine Society 2008
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613050/
https://ncbi.nlm.nih.gov/pubmed/18669595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0836
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