Evaluation of Small Molecule Modulators of the Luteinizing Hormone/Choriogonadotropin and Thyroid Stimulating Hormone Receptors: Structure Activity Relationships and Selective Binding Patterns

The substituted thieno[2,3-d]pyrimidine 3 (Org 41841), a partial agonist for the luteinizing hormone/choriogonadotropin receptor (LHCGR) and the closely related thyroid-stimulating hormone receptor (TSHR), was fundamentally altered and the resulting analogues were analyzed for their potencies, effic...

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Main Authors: Moore, Susanna, Jaeschke, Holger, Kleinau, Gunnar, Neumann, Susanne, Costanzi, Stefano, Jiang, Jian-kang, Childress, John, Raaka, Bruce M., Colson, Anny, Paschke, Ralf, Krause, Gerd, Thomas, Craig J., Gershengorn, Marvin C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543117/
https://ncbi.nlm.nih.gov/pubmed/16789744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060247s
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