A Low-Molecular-Weight Antagonist for the Human Thyrotropin Receptor with Therapeutic Potential for Hyperthyroidism

Low-molecular-weight (LMW) antagonists for TSH receptor (TSHR) may have therapeutic potential as orally active drugs to block stimulating antibodies (TsAbs) in Graves’ hyperthyroidism. We describe an approach to identify LMW ligands for TSHR based on Org41841, a LMW partial agonist for the LH/chorio...

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Xehetasun bibliografikoak
Egile Nagusiak: Neumann, Susanne, Kleinau, Gunnar, Costanzi, Stefano, Moore, Susanna, Jiang, Jian-kang, Raaka, Bruce M., Thomas, Craig J., Krause, Gerd, Gershengorn, Marvin C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Endocrine Society 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613050/
https://ncbi.nlm.nih.gov/pubmed/18669595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0836
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