A Drug-Like Antagonist Inhibits Thyrotropin Receptor–Mediated Stimulation of cAMP Production in Graves' Orbital Fibroblasts

BACKGROUND: Fibroblasts (FIBs) within the retro-orbital space of patients with Graves' disease (GOFs) express thyrotropin receptors (TSHRs) and are thought to be an orbital target of TSHR-stimulating autoantibodies in Graves' ophthalmopathy (GO). Recently, we developed a low molecular weig...

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Main Authors: Neumann, Susanne, Pope, Arthur, Geras-Raaka, Elizabeth, Raaka, Bruce M., Bahn, Rebecca S., Gershengorn, Marvin C.
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2012
Assuntos:
Immunology, Autoimmunity, and Graves' Ophthalmopathy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407388/
https://ncbi.nlm.nih.gov/pubmed/22784331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2011.0520
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