A Small Molecule Antagonist Inhibits Thyrotropin Receptor Antibody-Induced Orbital Fibroblast Functions Involved in the Pathogenesis of Graves Ophthalmopathy

CONTEXT: Graves ophthalmopathy (GO) is an autoimmune disorder characterized by increased adipogenesis and hyaluronan (HA) production by orbital fibroblasts. Circulating autoantibodies (thyroid-stimulating antibodies [TSAbs]) directed at the thyrotropin receptor (TSHR) on these cells stimulate or aug...

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Detalhes bibliográficos
Main Authors: Turcu, Adina F., Kumar, Seema, Neumann, Susanne, Coenen, Michael, Iyer, Seethalakshmi, Chiriboga, Pamela, Gershengorn, Marvin C., Bahn, Rebecca S.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Endocrine Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644605/
https://ncbi.nlm.nih.gov/pubmed/23482611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2013-1149
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