A Stimulatory Thyrotropin Receptor Antibody Enhances Hyaluronic Acid Synthesis in Graves' Orbital Fibroblasts: Inhibition by an IGF-I Receptor Blocking Antibody

CONTEXT: Graves' ophthalmopathy (GO) is characterized by expanded volume of the orbital fat and extraocular muscle tissues and elevated levels of TSH receptor autoantibodies (TRAb). The expansion of orbital tissues involves accumulation of hyaluronic acid (HA) within the orbit. OBJECTIVE: The o...

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Main Authors: Kumar, Seema, Iyer, Seethalakshmi, Bauer, Hilary, Coenen, Michael, Bahn, Rebecca S.
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2012
Assuntos:
Endocrine Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339886/
https://ncbi.nlm.nih.gov/pubmed/22399503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2011-2890
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