A Stimulatory Thyrotropin Receptor Antibody (M22) and Thyrotropin Increase Interleukin-6 Expression and Secretion in Graves' Orbital Preadipocyte Fibroblasts

BACKGROUND: Patients with Graves' ophthalmopathy (GO) have circulating autoantibodies directed against the thyrotropin receptor (TSHR) and elevated levels of the proinflammatory cytokine interleukin-6 (IL-6) in both serum and orbital tissues. We hypothesized that these autoantibodies might incr...

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Detalhes bibliográficos
Main Authors: Kumar, Seema, Schiefer, Reagan, Coenen, Michael J., Bahn, Rebecca S.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
Assuntos:
Original Studies, Reviews, and Scholarly Dialog
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833174/
https://ncbi.nlm.nih.gov/pubmed/20017620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2009.0278
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