Persistent cAMP signaling by thyrotropin (TSH) receptors is not dependent on internalization

Evidence was presented that thyrotropin [thyroid-stimulating hormone (TSH)]-stimulated persistent cAMP signaling is dependent on receptor (with G-protein α subunits and adenylyl cyclase) internalization. Because it is not clear whether G proteins and adenylyl cyclase internalize with receptors, we t...

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Главные авторы: Neumann, Susanne, Geras-Raaka, Elizabeth, Marcus-Samuels, Bernice, Gershengorn, Marvin C.
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2010
Предметы:
Research Communications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996905/
https://ncbi.nlm.nih.gov/pubmed/20538910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-161745
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