TSH Receptor Homodimerization in Regulation of cAMP Production in Human Thyrocytes in vitro

Thyrotropin hormone (TSH) was reported to exhibit biphasic regulation of cAMP production in human thyroid slices; specifically, upregulation at low TSH doses transitioning to inhibition at high doses. We observed this phenomenon in HEK293 cells overexpressing TSH receptors (TSHRs) but in only 25% of...

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Detalhes bibliográficos
Publicado no:Front Endocrinol (Lausanne)
Main Authors: Boutin, Alisa, Krieger, Christine C., Marcus-Samuels, Bernice, Klubo-Gwiezdzinska, Joanna, Neumann, Susanne, Gershengorn, Marvin C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203478/
https://ncbi.nlm.nih.gov/pubmed/32425890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2020.00276
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