Thyrotropin Causes Dose-dependent Biphasic Regulation of cAMP Production Mediated by G(s) and G(i/o) Proteins

The thyrotropin (TSH) receptor (TSHR) signals via G proteins of all four classes and β-arrestin 1. Stimulation of TSHR leads to increasing cAMP production that has been reported as a monotonic dose-response curve that plateaus at high TSH doses. In HEK 293 cells overexpressing TSHRs (HEK-TSHR cells)...

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Publicado en:Mol Pharmacol
Main Authors: Neumann, Susanne, Malik, Sarah S., Marcus-Samuels, Bernice, Eliseeva, Elena, Jang, Daesong, Klubo-Gwiezdzinska, Joanna, Krieger, Christine C., Gershengorn, Marvin C.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2020
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6864415/
https://ncbi.nlm.nih.gov/pubmed/31704717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.117382
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