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Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor
The thyrotropin receptor (TSHR) exhibits elevated cAMP signaling in the basal state and becomes fully activated by thyrotropin. Previously we presented evidence that small-molecule ligands act allosterically within the transmembrane region in contrast to the orthosteric extra-cellular hormone-bindin...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3099415/ https://ncbi.nlm.nih.gov/pubmed/20652618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-010-0451-2 |
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