Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor

The thyrotropin receptor [thyroid-stimulating hormone receptor (TSHR)], a G-protein-coupled receptor (GPCR), is endogenously activated by thyrotropin, which binds to the extracellular region of the receptor. We previously identified a low-molecular-weight (LMW) agonist of the TSHR and predicted its...

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Detalhes bibliográficos
Main Authors: Kleinau, Gunnar, Haas, Ann-Karin, Neumann, Susanne, Worth, Catherine L., Hoyer, Inna, Furkert, Jens, Rutz, Claudia, Gershengorn, Marvin C., Schülein, Ralf, Krause, Gerd
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2010
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230523/
https://ncbi.nlm.nih.gov/pubmed/20179143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-149146
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