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Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor
The thyrotropin receptor [thyroid-stimulating hormone receptor (TSHR)], a G-protein-coupled receptor (GPCR), is endogenously activated by thyrotropin, which binds to the extracellular region of the receptor. We previously identified a low-molecular-weight (LMW) agonist of the TSHR and predicted its...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Federation of American Societies for Experimental Biology
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3230523/ https://ncbi.nlm.nih.gov/pubmed/20179143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-149146 |
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