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Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor

The thyrotropin receptor (TSHR) exhibits elevated cAMP signaling in the basal state and becomes fully activated by thyrotropin. Previously we presented evidence that small-molecule ligands act allosterically within the transmembrane region in contrast to the orthosteric extra-cellular hormone-bindin...

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Bibliografiske detaljer
Main Authors: Haas, Ann-Karin, Kleinau, Gunnar, Hoyer, Inna, Neumann, Susanne, Furkert, Jens, Rutz, Claudia, Schülein, Ralf, Gershengorn, Marvin C., Krause, Gerd
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099415/
https://ncbi.nlm.nih.gov/pubmed/20652618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-010-0451-2
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