NMR in the Analysis of Functional Chemokine Interactions and Drug Discovery

Por Ziarek, Joshua J., Volkman, Brian F.
Publicado em 2012

Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology

Por Ziarek, Joshua J., Baptista, Diego B., Wagner, Gerhard
Publicado no J Mol Med (Berl) (2017)

Bicelle size modulates the rate of bacteriorhodopsin folding

Por Gruenhagen, Timothy C., Ziarek, Joshua J., Schlebach, Jonathan P.
Publicado no Protein Sci (2018)

A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability

Por Takekoshi, Tomonori, Ziarek, Joshua J., Volkman, Brian F., Hwang, Sam T.
Publicado em 2012

Examining weak protein-protein interactions in start codon recognition via nuclear magnetic resonance spectroscopy

Por Luna, Rafael E., Akabayov, Sabine R., Ziarek, Joshua J., Wagner, Gerhard
Publicado em 2014

Binding site identification and structure determination of protein-ligand complexes by NMR

Por Ziarek, Joshua J., Peterson, Francis C., Lytle, Betsy L., Volkman, Brian F.
Publicado em 2011

Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure based drug design

Por Veldkamp, Christopher T., Ziarek, Joshua J., Peterson, Francis C., Chen, Yu, Volkman, Brian F.
Publicado em 2010

Sulfotyrosine Recognition as Marker for Druggable Sites in the Extracellular Space

Por Ziarek, Joshua J., Heroux, Maxime S., Veldkamp, Christopher T., Peterson, Francis C., Volkman, Brian F.
Publicado em 2011

Discovery and Characterization of a Disulfide-Locked C(2)-Symmetric Defensin Peptide

Por Wommack, Andrew J., Ziarek, Joshua J., Tomaras, Jill, Chileveru, Haritha R., Zhang, Yunfei, Wagner, Gerhard, Nolan, Elizabeth M.
Publicado em 2014

The CXC Chemokine Receptor 4 Ligands Ubiquitin and Stromal Cell-derived Factor-1α Function through Distinct Receptor Interactions

Por Saini, Vikas, Staren, Daniel M., Ziarek, Joshua J., Nashaat, Zayd N., Campbell, Edward M., Volkman, Brian F., Marchese, Adriano, Majetschak, Matthias
Publicado em 2011

Structural Analysis of a Novel Small Molecule Ligand Bound to the CXCL12 Chemokine

Por Smith, Emmanuel W., Liu, Yan, Getschman, Anthony E., Peterson, Francis C., Ziarek, Joshua J., Li, Rongshi, Volkman, Brian F., Chen, Yu
Publicado no J Med Chem (2014)

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

Por Drury, Luke J., Ziarek, Joshua J., Gravel, Stéphanie, Veldkamp, Christopher T., Takekoshi, Tomonori, Hwang, Samuel T., Heveker, Nikolaus, Volkman, Brian F., Dwinell, Michael B.
Publicado em 2011

New paradigms in chemokine receptor signal transduction: moving beyond the two-site model

Por Kleist, Andrew B., Getschman, Anthony E., Ziarek, Joshua J., Nevins, Amanda M., Gauthier, Pierre-Arnaud, Chevigné, Andy, Szpakowska, Martyna, Volkman, Brian F.
Publicado no Biochem Pharmacol (2016)

Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12

Por Veldkamp, Christopher T, Ziarek, Joshua J, Su, Jidong, Basnet, Harihar, Lennertz, Richard, Weiner, Joshua J, Peterson, Francis C, Baker, John E, Volkman, Brian F
Publicado em 2009

Fragment-Based Optimization of Small Molecule CXCL12 Inhibitors for Antagonizing the CXCL12/CXCR4 Interaction

Por Ziarek, Joshua J., Liu, Yan, Smith, Emmanuel, Zhang, Guolin, Peterson, Francis C., Chen, Jun, Yu, Yongping, Chen, Yu, Volkman, Brian F., Li, Rongshi
Publicado em 2012

Structure-based ligand discovery for the protein–protein interface of chemokine receptor CXCR4

Por Mysinger, Michael M., Weiss, Dahlia R., Ziarek, Joshua J., Gravel, Stéphanie, Doak, Allison K., Karpiak, Joel, Heveker, Nikolaus, Shoichet, Brian K., Volkman, Brian F.
Publicado em 2012

Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery

Por Ziarek, Joshua J., Getschman, Anthony E., Butler, Stephen J., Taleski, Deni, Stephens, Bryan, Kufareva, Irina, Handel, Tracy M., Payne, Richard J., Volkman, Brian F.
Publicado em 2013

(15)N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins

Por Chhabra, Sandeep, Fischer, Patrick, Takeuchi, Koh, Dubey, Abhinav, Ziarek, Joshua J., Boeszoermenyi, Andras, Mathieu, Daniel, Bermel, Wolfgang, Davey, Norman E., Wagner, Gerhard, Arthanari, Haribabu
Publicado no Proc Natl Acad Sci U S A (2018)

Solution structure of CCL21 and identification of a putative CCR7 binding site

Por Love, Melissa, Sandberg, Jamie L., Ziarek, Joshua J., Gerarden, Kyle P., Rode, Renee R., Jensen, Davin R., McCaslin, Darrell R., Peterson, Francis C., Veldkamp, Christopher T.
Publicado em 2012

Heparin Oligosaccharides Inhibit Chemokine (CXC Motif) Ligand 12 (CXCL12) Cardioprotection by Binding Orthogonal to the Dimerization Interface, Promoting Oligomerization, and Compe...

Por Ziarek, Joshua J., Veldkamp, Christopher T., Zhang, Fuming, Murray, Nathan J., Kartz, Gabriella A., Liang, Xinle, Su, Jidong, Baker, John E., Linhardt, Robert J., Volkman, Brian F.
Publicado em 2013