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Structure-based ligand discovery for the protein–protein interface of chemokine receptor CXCR4
G-protein–coupled receptors (GPCRs) are key signaling molecules and are intensely studied. Whereas GPCRs recognizing small-molecules have been successfully targeted for drug discovery, protein-recognizing GPCRs, such as the chemokine receptors, claim few drugs or even useful small molecule reagents....
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3325704/ https://ncbi.nlm.nih.gov/pubmed/22431600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120431109 |
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