Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12

Atypical chemokine receptors do not mediate chemotaxis or G protein signaling, but they recruit arrestin. They also efficiently scavenge their chemokine ligands, thereby contributing to gradient maintenance and termination. ACKR3, also known as CXCR7, binds and degrades the constitutive chemokine CX...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Benredjem, Besma, Girard, Mélanie, Rhainds, David, St.-Onge, Geneviève, Heveker, Nikolaus
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217689/
https://ncbi.nlm.nih.gov/pubmed/27875312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762252
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