Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3–mediated chemokine scavenging

The atypical chemokine receptor ACKR3 contributes to chemotaxis by binding, internalizing, and degrading the chemokines CXCL11 and CXCL12 to shape and terminate chemotactic gradients during development and immune responses. Although unable to trigger G protein activation, both ligands activate G pro...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Principais autores: Montpas, Nicolas, St-Onge, Geneviève, Nama, Nassr, Rhainds, David, Benredjem, Besma, Girard, Mélanie, Hickson, Gilles, Pons, Véronique, Heveker, Nikolaus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777261/
https://ncbi.nlm.nih.gov/pubmed/29180449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.814947
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